Ocular manifestation of HIV-positive patients in VCT clinic of tertiary hospital in bali, indonesia
Main Article Content
Keywords
Human Immunodeficiency Virus, ocular manifestations, characteristic, Bali
Abstract
Introduction: Human Immunodeficiency Virus (HIV) and Acquired Immuno Deficiency Syndrome (AIDS) have become health problems that causing complications in the eye. This study was structured to determine the characteristics, description of ocular manifestations and their relationship with CD4 levels and HIV RNA.
Method: This is a descriptive study, conducted June to November 2020. The samples taken were selected by snowball sampling of patients with HIV infection who a attended the VCT clinic Sanglah General Hospital Bali, Indonesia. Data analysis was performed using characteristic analysis and the relationship between variables was analyzed using the chi-square method.
Result: A total of 71 HIV patients including 57.7% male and 42.3% female. Majority patients age group is those who were more than 40 years old (54.9%) and from Denpasar (52.11%). About 52.1% of patients had been diagnosed with HIV for 1-5 years, with 91.5% were having received ART therapy. Of a total of 28 out of 71 patients (39.4%) had HIV-related ocular manifestations.
Conclusion: Ocular manifestations occurred more frequently at detectable viral load levels and CD4 counts of 250-500 cells/µL. There was no significant association between ocular manifestations and CD4 and HIV RNA levels with almost the same prevalence in men and women. Voluntary eye examinations by asymptomatic HIV patients are still difficult.
References
2. Ministry of Health RI. 2015. National Action Plan for HIV-AIDS Control 2015 - 2019.
3. Peters RP, Kestelyn PG, Zierhut M, Kempen J H. 2020. The Changing Global Epidemic of HIV and Ocular Disease. Ocular Immunology And Inflammation, page: 1007-1014. https://doi.org/10.1080/09273948.2020.1751214
4. Copeland R. 2019. Ocular Manifestations of HIV Infection. Viewed July 2nd 2020. Avalaible on < https://emedicine.medscape.com/article/1216172-overview>
5. Bekele S, Gelaw Y, Tessema F. 2013. Ocular Manifestation Of HIV / AIDS And Correlation With CD4 + Cells Count Among Adult HIV / AIDS Patients In Jimma Town, Ethiopia: A Cross Sectional Study. BMC Ophthalmology, 13:20. https://dx.doi.org/10.1186%2F1471-2415-13-20
6. Singalavanija T, Ausayakhun S, Tangmonkongvoragul C. 2018. Anterior Segment And External Ocular Disorders Associated With HIV Infections In The Era Of HAART In Chiang Mai University Hospital, A Prospective Descriptive Cross Sectional Study.PLoS ONE13 (2): e0193161. https://doi.org/10.1371/journal.pone.019316
7. Sharma M, Chauhan A, Sharma G, Chauhan V. 2018. Ocular Manifestations In Patients Attending Antiretroviral Therapy Center At A Tertiary Care Hospital In Himachal Pradesh, India. Indian Journal Of Medical Research. Volume: 147. Issue: 5. Page: 496-500. https://dx.doi.org/10.4103%2Fijmr.IJMR_1037_15
8. Hothi HS, Gohil NR, Parekh NV, Patel S S. 2019. A Prevalence Study Of Ocular Manifestation in HIV Positive Patients on Highly Active Anti - Retroviral Therapy. International Journal Of Community Medicine and Public Health. Vol 6 Issue 7. Page 2950 - 4.DOI: 10.15761 / BRCP.1000186
9. Kumarasamy N, Solomon S, Chaguturu SK, Cecelia AJ, Vallabhaneni S, Flanigan T P. 2005. The changing natural history of HIV disease: before and after the introduction of generic antiretroviral therapy in southern India. Clin Infect Dis, 41: 1525–8. https://doi.org/10.1086/497267
10. Amsalu, A., Desta, K., Nigussie, D., & Delelegne, D. 2017. Ocular manifestation and their associated factors among HIV / AIDS patients receiving highly active antiretroviral therapy in Southern Ethiopia. International journal of ophthalmology, 10 (5), 776–781.https://doi.org/10.18240/ijo.2017.05.20
11. Gowda HT, Krishnamurthy T, Tanushree V, Nayak S. 2015. Correlation of CD4 count and severity of dry eye in human immunodeficiency virus positive patients. Int J Sci Stud; 3 (5): 68–71.
12. Sharew G, & Azage, M. 2015. Predictors of HIV / AIDS Related Ocular Manifestations among HIV / AIDS Patients in Felege Hiwot Referral Hospital, Northwest Ethiopia. Journal of Ophthalmology, 2015, 1–7. doi: 10.1155/2015 / 965627
13. Labh RK, Chaudhary M, Shah D N. Eye Changes Among HIV Positive Patients On Antiretroviral Therapy In Nepal. Nepal J Ophthalmol. 2016; 8 (15): 62-70.doi: 10.3126 / nepjoph.v8i1.16158.
14. Abu EK, Abokyi S, Yeboah DO, Ephraim RKD, Afedo D, Agyeman LD, Kusi SB B. 2016. Retinal Microvasculopathy Is Common in HIV / AIDS Patients: A Cross-Sectional Study at the Cape Coast Teaching Hospital, Ghana. Journal of Ophthalmology, 8614095. https://doi.org/10.1155/2016/8614095
15. Di Y, Zhao XY, Ye JJ, Li B, Ma N. 2019. Fundus Manifestation and HIV Viral loads of AIDS Patients Before and After HAART. International Journal Of Ophthalmology, vol 12 (9), 1438-1443. https://dx.doi.org/10.18240%2Fijo.2019.09.11
16. Davis J L. 2020. Ocular Involvement in HIV / AIDS.Viewed July 2nd 2020. Avalaible on: < https://eyewiki.aao.org/Ocular_Involvement_in_HIV/AIDS>.
17. Mathebula SD & Makunyane P S. 2018. Ocular Surface Disorder Among HIV And AIDS Patients Using Antiretroviral Drugs. Afr Vision Eye Health. 2019; 78 (1), a457. https://doi.org/10.4102/aveh.v78i1.457